Effect of exercise rehabilitation, neuromuscular muscle stimulation, and massage on ischemic stroke recovery and hypertension: a randomized trial

Authors

  • Ammar Hadi University of Babylon
  • Shimal H. Hamad soran university
  • Nabaz Ali Ahmed University of Raparin

DOI:

https://doi.org/10.47197/retos.v70.113694

Keywords:

Ischemic stroke, whole-body exercise, neuromuscular stimulation, massage, rehabilitation, hypertension

Abstract

Introduction: Stroke is among the top five causes of death and a leading cause of long-term disability worldwide. Ischemic stroke (IS), the most common type, results from an obstruction within a blood vessel supplying blood to the brain. Hemiparesis affects approximately 65% of stroke survivors, significantly impacting the quality of life.

Objective: This study aimed to examine the effects of whole-body exercise (WBE), electrical neuromuscular stimulation (ENS), and massage therapy on facial and body muscle strength, stroke severity, visual acuity, and blood pressure among patients with ischemic stroke.

Methods: A prospective, randomised, controlled trial was conducted with 180 male IS patients who met the eligibility criteria for thrombolytic treatment. Participants were randomly assigned to either an experimental group (n = 90) that received WBE, ENS, and massage or a control group (n = 90) that followed standard hospital rehabilitation. The intervention lasted 12 weeks, consisting of four 30–40-minute sessions per week. Outcomes were assessed pre- and post-intervention using validated measures: the Los Angeles Motor Scale (LAMS), the Iowa Oral Performance Instrument (IOPI), the MRC muscle scale, and standard blood pressure and visual acuity assessments. Statistical analyses included ANCOVA, with effect sizes reported.

Results: The experimental group demonstrated improvements in stroke severity, muscle strength, and visual acuity; however, several outcomes did not reach statistical significance (e.g., MCS, p = 0.075; SBP, p = 0.092). No significant group differences in body weight were observed. Dropout rates and missing data were not reported.

Conclusion: While some outcomes showed promising trends, the lack of statistical significance for several key measures limits the strength of conclusions. Caution is warranted when interpreting these findings, and further studies are needed with improved methodology and larger samples.

References

Ai, X., Chen, L., Lan, Y., Liu, B., Song, P., Wang, J., & Zhang, Z. (2024). Efficacy and safety of a noninvasive, home‐based radiofrequency device for facial rejuvenation: An open‐label, intra-individual controlled trial. Journal of Cosmetic Dermatology, 23(3), 862-868.

Budinčević, H., Meštrović, A., & Demarin, V. (2022). Stroke scales as assessment tools in emergency settings: a narrative review. Medicina, 58(11), 1541.

Cabanas-Valdés, R., Calvo-Sanz, J., Serra-Llobet, P., Alcoba-Kait, J., González-Rueda, V., & Rodríguez-Rubio, P. R. (2021). The effectiveness of massage therapy for improving sequelae in post-stroke survivors. A systematic review and meta-analysis. International journal of environmen-tal research and public health, 18(9), 4424.

Caplan, L. R., Simon, R. P., & Hassani, S. (2023). Cerebrovascular disease—stroke. In Neurobiology of brain disorders (pp. 457-476). Elsevier.

Chalchat, E., Gennisson, J.-L., Peñailillo, L., Oger, M., Malgoyre, A., Charlot, K., Bourrilhon, C., Siracusa, J., & Garcia-Vicencio, S. (2020). Changes in the viscoelastic properties of the vastus lateralis muscle with fatigue. Frontiers in physiology, 11, 307.

Cheng, K., Wang, Z., Bai, J., Xiong, J., Chen, J., & Ni, J. (2022). Research advances in the application of vagus nerve electrical stimulation in ischemic stroke. Frontiers in Neuroscience, 16, 1043446.

Choi, A.-Y., Lim, J.-H., & Kim, B.-G. (2024). Effects of muscle strength exercise on muscle mass and mus-cle strength in patients with stroke: a systematic review and meta-analysis. Journal of Exercise Rehabilitation, 20(5), 146.

Choi, J.-B. (2016). Effect of neuromuscular electrical stimulation on facial muscle strength and oral function in stroke patients with facial palsy. Journal of physical therapy science, 28(9), 2541-2543.

Erzincanli, S., & Kasar, K. S. (2021). Effect of hand massage on pain, anxiety, and vital signs in patients before venipuncture procedure: A randomised controlled trial. Pain Management Nursing, 22(3), 356-360.

Gattner, H., Adamiak, J., Piotrowska, A., Czerwińska-Ledwig, O., Mętel, S., Kępińska-Szyszkowska, M., & Pilch, W. (2023). Effect of Whole-Body Vibration Training on Hemorheological Blood Indices in Young, Healthy Women. International journal of environmental research and public health, 20(4), 3232.

Hamp, A., Anderson, J., Laughter, M. R., Anderson, J. B., Presley, C. L., Rundle, C. W., & Dellavalle, R. P. (2023). Gua‐sha, Jade Roller, and Facial Massage: Are there benefits within dermatology? Jour-nal of Cosmetic Dermatology, 22(2).

Hayashi, N., & Du, L. (2021). Acute and chronic periocular massage for ocular blood flow and vision: a randomised controlled trial. International Journal of Therapeutic Massage & Bodywork, 14(2), 5.

Hernández Niño, J. D., Pitombeira Pereira-Pedro, K., Mollinedo Cardalda, I., & Machado de Oliveira, I. (2022a). Electroestimulación funcional para miembros superiores tras el accidente cerebro-vascular: una revisión sistemática (Functional electrostimulation for upper limbs after stroke: a systematic review). Retos, 46, 1073-1083. https://doi.org/10.47197/retos.v46.93934

Hernández Niño, J. D., Pitombeira Pereira-Pedro, K., Mollinedo Cardalda, I., & Machado de Oliveira, I. (2022b). Functional electrostimulation for upper limbs after stroke: a systematic review. Retos, 46, 1073-1083. https://doi.org/10.47197/retos.v46.93934

Holmes, C. J., & Hastings, M. K. (2021). The application of exercise training for diabetic peripheral neu-ropathy. Journal of Clinical Medicine, 10(21), 5042.

Jabbarzadeh Ganjeh, B., Zeraattalab-Motlagh, S., Jayedi, A., Daneshvar, M., Gohari, Z., Norouziasl, R., Ghaemi, S., Selk-Ghaffari, M., Moghadam, N., & Kordi, R. (2024). Effects of aerobic exercise on blood pressure in patients with hypertension: a systematic review and dose-response meta-analysis of randomised trials. Hypertension Research, 47(2), 385-398.

Jolugbo, P., & Ariëns, R. A. (2021). Thrombus composition and efficacy of thrombolysis and thrombec-tomy in acute ischemic stroke. Stroke, 52(3), 1131-1142.

Kartush, J. M., Rice, K. S., Minahan, R. E., Balzer, G. K., Yingling, C. D., & Seubert, C. N. (2021). Best prac-tices in facial nerve monitoring. The Laryngoscope, 131, S1-S42.

Kawahira, K., Shimodozono, M., & Noma, T. (2022). Exercise therapy for recovery from hemiplegia: theory and practice of repetitive facilitative exercise. Springer Nature.

Kleyweg, R., Van der Meche, F., & Meulstee, J. (1988). Treatment of Guillain‐Barré syndrome with high‐dose gammaglobulin. Neurology, 38(10), 1639-1639.

Lamott, A. (2022). Muscular System, Pathologies, Disorders, and Injuries. Massage Therapy E-Book: Massage Therapy E-Book, 438.

Makofsky, H. W. (2024). Spinal manual therapy: an introduction to soft tissue mobilisation, spinal ma-nipulation, therapeutic and home exercises. Taylor & Francis.

Mauro, G., Verdecchia, A., Suárez-Fernández, C., Nocini, R., Mauro, E., & Zerman, N. (2024). Temporo-mandibular Disorders Management—What's New? A Scoping Review. Dentistry Journal, 12(6), 157.

Moghadasi, A., Ghasemi, G., Sadeghi-Demneh, E., & Etemadifar, M. (2020). The effect of total body re-sistance exercise on mobility, proprioception, and muscle strength of the knee in people with multiple sclerosis. Journal of Sport Rehabilitation, 29(2), 192-199.

Murphy, S. J., & Werring, D. J. (2020). Stroke: causes and clinical features. Medicine, 48(9), 561-566.

Muzyka, I. M., & Estephan, B. (2018). Electrophysiology of cranial nerve testing: trigeminal and facial nerves. Journal of Clinical Neurophysiology, 35(1), 16-24.

Ni, B., Jin, H., & Wu, W. (2024). Therapeutic effect of proprioceptive neuromuscular facilitation combi-ned with muscle energy technique on post-stroke dysphagia. Technology and Health Care, 32(6), 4331-4342.

Paschall, A., Khan, A. A., Enam, S. F., Boggs, T., Hijazi, G., Bowling, M., Austin, S., Case, L. E., & Kishnani, P. (2021). Physical therapy assessment and whole-body magnetic resonance imaging findings in children with glycogen storage disease type IIIa: A clinical study and review of the literature. Molecular genetics and metabolism, 134(3), 223-234.

Phipps, M. S., & Cronin, C. A. (2020). Management of acute ischemic stroke. Bmj, 368.

Pietrosimone, B., Lepley, A. S., Kuenze, C., Harkey, M. S., Hart, J. M., Blackburn, J. T., & Norte, G. (2022). Arthrogenic muscle inhibition following anterior cruciate ligament injury. Journal of Sport Rehabilitation, 31(6), 694-706.

Prior, P. L., & Suskin, N. (2018). Exercise for stroke prevention. Stroke and Vascular Neurology, 3(2).

Rommel, F., Lüken, S., Prasuhn, M., Kurz, M., Kakkassery, V., Grisanti, S., & Ranjbar, M. (2020). Evalua-ting retinal and choroidal perfusion changes after ocular massage of healthy eyes using optical coherence tomography angiography. Medicina, 56(12), 645.

Samak, Z. A., Clatworthy, P., & Mirmehdi, M. (2024). Automatic Prediction of Stroke Treatment Outco-mes: Latest Advances and Perspectives. arXiv preprint arXiv:2412.04812.

Shahid, J., Kashif, A., & Shahid, M. K. (2023). A comprehensive review of physical therapy interventions for stroke rehabilitation: impairment-based approaches and functional goals. Brain Sciences, 13(5), 717.

Shahpasand, S., Khatami, S. H., Ehtiati, S., Alehossein, P., Salmani, F., Toutounchi, A. H., Zarei, T., Shahmohammadi, M. R., Khodarahmi, R., & Aghamollaii, V. (2024). Therapeutic Potential of the Ketogenic Diet: A Metabolic Switch with Implications for Neurological Disorders, the Gut-Brain Axis, and Cardiovascular Diseases. The Journal of Nutritional Biochemistry, 109693.

Tamborini, A. (2023). A Novel Approach to Cardiac Health Assessment Using a Redesign of the Bra-chial Cuff Device. California Institute of Technology.

Teasell, R., Salbach, N. M., Foley, N., Mountain, A., Cameron, J. I., Jong, A. d., Acerra, N. E., Bastasi, D., Carter, S. L., & Fung, J. (2020). Canadian stroke best practice recommendations: rehabilitation, recovery, and community participation following stroke. Part one: rehabilitation and recovery following stroke; update 2019. International Journal of Stroke, 15(7), 763-788.

Tosto-Mancuso, J., Tabacof, L., Herrera, J. E., Breyman, E., Dewil, S., Cortes, M., Correa-Esnard, L., Kell-ner, C. P., Dangayach, N., & Putrino, D. (2022). Gamified neurorehabilitation strategies for post-stroke motor recovery: challenges and advantages. Current Neurology and Neuroscience Re-ports, 22(3), 183-195.

Trentmann, F. (2020). Disruption is normal: blackouts, breakdowns and the elasticity of everyday life. In time, consumption and everyday life (pp. 67-84). Routledge.

Wu, M., Chen, J., Ma, Y., Yan, B., Pan, M., Peng, Q., Wang, W., Han, L., Liu, J., & Zeng, H. (2020). Ultra elastic, stretchable, self-healing conductive hydrogels with tunable optical properties for highly sensitive soft electronic sensors. Journal of Materials Chemistry A, 8(46), 24718-24733.

Yoo, M. C., Kim, J. H., Kim, Y. J., Jung, J., Kim, S. S., Kim, S. H., & Yeo, S. G. (2023). Effects of electrical stimulation on facial paralysis recovery after facial nerve injury: a review on preclinical and clinical studies. Journal of Clinical Medicine, 12(12), 4133.

Yunus, M., Aditya, RS, Sulistyorini, A., Darmawan, A., Wahyudi, NT, AlMutairi, RI y Razeeni, DMA (2024). "¿Qué hará el cuidador?" en casa para el ejercicio en silla de ruedas tras un ictus: inves-tigación cualitativa desde la perspectiva de profesionales de la salud multidisciplina-rios. Retos , 59 , 776–787. https://doi.org/10.47197/retos.v59.105219

Zapata-Soria, M., Cabrera-Martos, I., López-López, L., Ortiz-Rubio, A., Granados-Santiago, M., Ríos-Asín, I., & Valenza, M. C. (2022). Clinical characteristics and rehabilitation strategies for the stoma-tognathic system disturbances in patients with stroke: a systematic review. International Jour-nal of Environmental Research and Public Health, 20(1), 657.

Zhang, L., Zhang, X., Sun, A., Cao, D., Cong, Z., & Liu, M. (2021). The research on rule of Acupoints and Massage Manipulations selection for Post-ischemic Stroke Constipation based on association rule and entropy clustering analysis. Med Data Min, 4(4), 19.

Downloads

Published

07/04/2025

Issue

Section

Original Research Article

How to Cite

Hadi, A., Hamad, S. H., & Ahmed, N. A. (2025). Effect of exercise rehabilitation, neuromuscular muscle stimulation, and massage on ischemic stroke recovery and hypertension: a randomized trial. Retos, 70, 533-545. https://doi.org/10.47197/retos.v70.113694