O efeito da intensidade do exercício na expressão de GLUT-2 pancreática e hepática em camundongos alimentados com alto teor de frutose
DOI:
https://doi.org/10.47197/retos.v57.104464Palavras-chave:
Obesity, Insulin resistance, GLUT-2 expression, Exercise, High fructoseResumo
O excesso de xarope de milho rico em frutose (HFCS) leva a distúrbios metabólicos caracterizados pela diminuição da expressão de GLUT-2 pancreático e aumento da expressão de GLUT-2 hepático. O exercício é relatado como uma terapia não farmacológica para melhorar distúrbios metabólicos. Este estudo tem como objetivo comparar diferenças na intensidade do exercício com alterações na expressão de GLUT-2 pancreática e hepática em camundongos induzidas por alto teor de frutose. Um total de 36 camundongos machos (Mus musculus), pesando 20-30 gramas, com 8 semanas de idade, foram divididos aleatoriamente em 4 grupos: C (Controle; n = 9), G1 (exercícios de natação em intensidade leve; n = 9), G2 (exercícios de natação de intensidade moderada; n = 9) e G3 (exercícios de natação de intensidade intensa; n = 9). Todos os grupos receberam uma solução de frutose a 30% por via oral (oralmente ad libitum) durante 8 semanas. Enquanto isso, o exercício de natação foi realizado 3 vezes por semana durante 8 semanas com três intensidades diferentes. A expressão de GLUT-2 pancreática e hepática foi medida por imuno-histoquímica (IHQ), e os resultados das medidas de expressão de GLUT-2 pancreática e hepática foram avaliados por escore imunorreativo (IRS). A análise do peso corporal por ANOVA unidirecional seguida pelo teste post hoc de diferença significativa honesta (HSD) de Tukey indica que G2 reduz significativamente o peso em comparação com C, G1 e G3 (p ≤ 0,05). A análise estatística foi realizada por meio do teste não paramétrico de Kruskal-Wallis e seguido do teste U de Mann-Whitney com nível de significância de 5%. Os dados mostraram que o G2 aumentou significativamente a expressão do GLUT-2 pancreático e diminuiu a expressão do GLUT-2 hepático em comparação com C, G1 e G3 (p ≤ 0,05). Em conclusão, o exercício de intensidade moderada tem o efeito ideal no aumento da expressão de GLUT-2 pancreático e na diminuição da expressão de GLUT-2 hepático.
Palavras-chave: Obesidade, Resistência à insulina, Expressão de GLUT-2, Exercício, Alto teor de frutose
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