Comparación de los efectos inmunológicos y fisiológicos entre el entrenamiento por intervalos de alta intensidad y el entrenamiento continuo de intensidad moderada en adultos físicamente inactivos

Autores/as

  • Muhammad Zuhaili Suhaimi 1.Centre for Fundamental and Continuing Education, Universiti Malaysia Terengganu (UMT), 21030 Kuala Nerus, Terengganu, MALAYSIA. 2.Exercise and Sports Science Programme, School of Health Sciences, Health Campus, Universiti Sains Malaysia (USM), 16150 Kubang Kerian, Kelantan, MALAYSIA.
  • Ayu Suzailiana Muhamad https://orcid.org/0000-0002-4854-6382
  • Chee Keong Chen
  • Foong Kiew Ooi
  • Marylin Li Yin Ong https://orcid.org/0000-0003-4608-8370
  • Rabiu Muazu Musa https://orcid.org/0000-0001-5332-1770

DOI:

https://doi.org/10.47197/retos.v70.115308

Palabras clave:

Salud ósea, aptitud cardiorrespiratoria, entrenamiento físico, función inmunológica

Resumen

Introducción: El Entrenamiento Interválico de Alta Intensidad (HIIT) y el Entrenamiento Continuo de Intensidad Moderada (MICT) son métodos de ejercicio eficaces para mejorar la condición física y la salud en personas sanas. Sin embargo, la investigación sobre su impacto en las respuestas inmunológicas y el metabolismo óseo en adultos físicamente inactivos es limitada.

Objetivo: Investigar los efectos del HIIT y el MICT sobre las respuestas inmunológicas, los marcadores del metabolismo óseo y ciertos parámetros fisiológicos en adultos físicamente inactivos.

Metodología: Treinta y seis adultos físicamente inactivos, de entre 18 y 35 años, fueron asignados aleatoriamente a los grupos de HIIT, MICT o control (n=12 en cada grupo). El grupo HIIT realizó 2 series de 6 a 8 repeticiones de 30 segundos de carrera al 85-95% de la frecuencia cardíaca máxima (FCmáx), tres veces por semana. El grupo MICT corrió durante 30 minutos al 55-70% de su FCmáx, también tres veces por semana, mientras que el grupo control no realizó ejercicio. Se tomaron muestras de consumo máximo de oxígeno (VO2máx), sangre y saliva antes y después de una intervención de 8 semanas.

Resultados: Tanto el HIIT como el MICT aumentaron significativamente los niveles de lisozima salival en comparación con los valores iniciales (p < 0.05), pero no se encontraron diferencias significativas entre los grupos (p > 0.05). Los recuentos totales de leucocitos y los marcadores del metabolismo óseo no mostraron cambios significativos entre los grupos. El consumo máximo de oxígeno mejoró únicamente en el grupo HIIT (p < 0.05).

Discusión: La mejora de la respuesta inmune después del HIIT y el MICT puede atribuirse a cambios hormonales resultantes de la producción de radicales libres durante el ejercicio extenuante.

Conclusiones: Tanto el HIIT como el MICT mejoran las respuestas inmunológicas sin afectar los marcadores del metabolismo óseo. El HIIT parece ser más efectivo que el MICT para mejorar el VO2 máx en adultos físicamente inactivos.

Citas

Abbasi, T., Nazarali, P., Hedayati, M., & Alizadeh, R. (2018). The effect of eight weeks of high intensity interval training on osteoponetin and some bone mineral indices in young women. Journal of Physical Education and Sport, 18(1), 532–535. https://doi.org/10.7752/jpes.2018.s176

Abd El-Kader, S. M., & Al-Shreef, F. M. (2018). Inflammatory cytokines and immune system modulation by aerobic versus resisted exercise training for elderly. African Health Sciences, 18(1), 120–131. https://doi.org/10.4314/ahs.v18i1.16

Amine. (2003). Diet, nutrition and the prevention of chronic diseases. World Health Organization Technical Report Series, 916(i-viii), 1-149.

Andersen, E., Bang-Kittilsen, G., Bigseth, T. T., Egeland, J., Holmen, T. L., Martinsen, E. W., Stensrud, T., & Engh, J. A. (2020). Effect of high-intensity interval training on cardiorespiratory fitness, physical activity and body composition in people with schizophrenia: a randomized controlled trial. BMC Psychiatry, 20(1), 425. https://doi.org/10.1186/s12888-020-02827-2

Anderson, E., & Durstine, J. L. (2019). Physical activity, exercise, and chronic diseases: A brief review. Sports Medicine and Health Science, 1(1), 3–10. https://doi.org/10.1016/j.smhs.2019.08.006

Bartlett, D. B., Shepherd, S. O., Wilson, O. J., Adlan, A. M., Wagenmakers, A. J. M., Shaw, C. S., & Lord, J. M. (2017). Neutrophil and Monocyte Bactericidal Responses to 10 Weeks of Low-Volume High-Intensity Interval or Moderate-Intensity Continuous Training in Sedentary Adults. Oxidative Medicine and Cellular Longevity, 2017, 8148742. https://doi.org/10.1155/2017/8148742

Bartlett, D. B., Slentz, C. A., Willis, L. H., Hoselton, A., Huebner, J. L., Kraus, V. B., Moss, J., Muehlbauer, M. J., Spielmann, G., Muoio, D. M., Koves, T. R., Wu, H., Huffman, K. M., Lord, J. M., & Kraus, W. E. (2020). Rejuvenation of Neutrophil Functions in Association With Reduced Diabetes Risk Following Ten Weeks of Low-Volume High Intensity Interval Walking in Older Adults With Prediabetes - A Pilot Study. Frontiers in Immunology, 11, 729. https://doi.org/10.3389/fimmu.2020.00729

Buchheit, M., & Laursen, P. B. (2013). High-intensity interval training, solutions to the programming puzzle: Part I: cardiopulmonary emphasis. Sports Medicine (Auckland, N.Z.), 43(5), 313–338. https://doi.org/10.1007/s40279-013-0029-x

Cabrera Linares, J. C., Latorre Román, P. Ángel, Párraga Montilla, J. A., Martínez Salazar, C., & Espinoza Silva, J. M. (2024). ¿Es el entrenamiento en intervalos de alta intensidad (HIIT) un método via-ble para mejorar los parámetros antropomórficos y cardiometabólicos en niños en edad prees-colar? (Is High Intensity Interval Training (HIIT) a feasible method for improving anthropo-morphic and cardiometabolic parameters in preschool children?). Retos, 61, 792–800. https://doi.org/10.47197/retos.v61.107878

Cao, M., Quan, M., & Zhuang, J. (2019). Effect of High-Intensity Interval Training versus Moderate-Intensity Continuous Training on Cardiorespiratory Fitness in Children and Adolescents: A Meta-Analysis. International Journal of Environmental Research and Public Health, 16(9). https://doi.org/10.3390/ijerph16091533

Cassidy, S., Thoma, C., Houghton, D., & Trenell, M. I. (2017). High-intensity interval training: a review of its impact on glucose control and cardiometabolic health. Diabetologia, 60(1), 7–23. https://doi.org/10.1007/s00125-016-4106-1

de Souza, D. C., Matos, V. A. F., dos Santos, V. O. A., Medeiros, I. F., Marinho, C. S. R., Nascimento, P. R. P., Dorneles, G. P., Peres, A., Müller, C. H., Krause, M., Costa, E. C., & Fayh, A. P. T. (2018). Effects of high-intensity interval and moderate-intensity continuous exercise on inflammatory, leptin, IgA, and lipid peroxidation responses in obese males. Frontiers in Physiology, 9(May), 1–9. https://doi.org/10.3389/fphys.2018.00567

Dolci, F., Kilding, A. E., Chivers, P., Piggott, B., & Hart, N. H. (2020). High-intensity interval training shock microcycle for enhancing sport performance: A brief review. Journal of Strength and Conditioning Research, 34(4), 1188–1196. https://doi.org/10.1519/JSC.0000000000003499

Eather, N., Riley, N., Miller, A., Smith, V., Poole, A., Vincze, L., Morgan, P. J., & Lubans, D. R. (2019). Efficacy and feasibility of HIIT training for university students: The Uni-HIIT RCT. Journal of Science and Medicine in Sport, 22(5), 596–601. https://doi.org/10.1016/j.jsams.2018.11.016

García-Pinillos, F., Cámara-Pérez, J. C., Soto-Hermoso, V. M., & Latorre-Román, P. Á. (2017). A High Intensity Interval Training (HIIT)-Based Running Plan Improves Athletic Performance by Improving Muscle Power. Journal of Strength and Conditioning Research, 31(1), 146–153. https://doi.org/10.1519/JSC.0000000000001473

Gleeson, M., McDonald, W. A., Cripps, A. W., Pyne, D. B., Clancy, R. L., & Fricker, P. A. (1995). The effect on immunity of long-term intensive training in elite swimmers. Clinical and Experimental Immunology, 102(1), 210–216. https://doi.org/10.1111/j.1365-2249.1995.tb06658.x

Hannan, A. L., Hing, W., Simas, V., Climstein, M., Coombes, J. S., Jayasinghe, R., Byrnes, J., & Furness, J. (2018). High-intensity interval training versus moderate-intensity continuous training within cardiac rehabilitation: a systematic review and meta-analysis. Open Access Journal of Sports Medicine, 9, 1–17. https://doi.org/10.2147/OAJSM.S150596

Jalalifarahani‎, S. (2021). The Effect of 6 Weeks of High-Intensity Exercise Training on Serum ‎ Calcium of Martial Arts Women. New Approaches in Exercise Physiology (NAEP), 3(6), 29–40. https://doi.org/10.22054/nass.2021.61152.1095

Julian, V., Costa, D., O’Malley, G., Metz, L., Fillon, A., Miguet, M., Cardenoux, C., Dutheil, F., Boirie, Y., Duclos, M., Courteix, D., Pereira, B., & Thivel, D. (2022). Bone Response to High-Intensity Interval Training versus Moderate-Intensity Continuous Training in Adolescents with Obesity. Obesity Facts, 15(1), 46–54. https://doi.org/10.1159/000519271

Karabulut, M., Bemben, D. A., Sherk, V. D., Anderson, M. A., Abe, T., & Michael, G. B. (2011). Effects of high-intensity resistance training and low-intensity resistance training with vascular restriction on bone markers in older men. European Journal of Applied Physiology, 111(8), 1659–1667. https://doi.org/10.1007/s00421-010-1796-9

Khammassi, M., Ouerghi, N., Said, M., Feki, M., Khammassi, Y., Pereira, B., Thivel, D., & Bouassida, A. (2018). Continuous moderate-intensity but not high-intensity interval training improves immune function biomarkers in healthy young men. Journal of Strength and Conditioning Research, 34(1), 249–256. https://doi.org/10.1519/JSC.0000000000002737

Khammassi, M., Ouerghi, N., Said, M., Feki, M., Khammassi, Y., Pereira, B., Thivel, D., & Bouassida, A. (2020). Continuous Moderate-Intensity but Not High-Intensity Interval Training Improves Immune Function Biomarkers in Healthy Young Men. Journal of Strength and Conditioning Research, 34(1), 249–256. https://doi.org/10.1519/JSC.0000000000002737

Lu, M., Li, M., Yi, L., Li, F., Feng, L., Ji, T., Zang, Y., & Qiu, J. (2022). Effects of 8-week High-Intensity Interval Training and Moderate-Intensity Continuous Training on Bone Metabolism in Sedentary Young Females. Journal of Exercise Science and Fitness, 20(2), 77–83. https://doi.org/10.1016/j.jesf.2022.01.001

Marques, A., Santos, T., Martins, J., Matos, M. G. De, & Valeiro, M. G. (2018). The association between physical activity and chronic diseases in European adults. European Journal of Sport Science, 18(1), 140–149. https://doi.org/10.1080/17461391.2017.1400109

Marterer, N., Menz, V., Amin, S., & Faulhaber, M. (2020). 6-week High-intensity Interval Training (HIIT) of the Lower Extremities Improves VO2max of the Upper Extremities. International Journal of Sports Medicine, 41(6), 380–390. https://doi.org/10.1055/a-1073-8016

Martin-Smith, R., Cox, A., Buchan, D. S., Baker, J. S., Grace, F., & Sculthorpe, N. (2020). High intensity interval training (HIIT) improves cardiorespiratory fitness (CRF) in healthy, overweight and obese adolescents: A systematic review and meta-analysis of controlled studies. International Journal of Environmental Research and Public Health, 17(8). https://doi.org/10.3390/ijerph17082955

McClean, C. M., Clegg, M., Shafat, A., Murphy, M. H., Trinick, T., Duly, E., McLaughlin, J., Fogarty, M., & Davison, G. W. (2011). The impact of acute moderate intensity exercise on arterial regional stiffness, lipid peroxidation, and antioxidant status in healthy males. Research in Sports Medicine, 19(1), 1–13. https://doi.org/10.1080/15438627.2011.534963

Milanović, Z., Sporiš, G., & Weston, M. (2015). Effectiveness of High-Intensity Interval Training (HIT) and Continuous Endurance Training for VO2max Improvements: A Systematic Review and Meta-Analysis of Controlled Trials. Sports Medicine (Auckland, N.Z.), 45(10), 1469–1481. https://doi.org/10.1007/s40279-015-0365-0

National Institute of Health (NIH)/ Ministry of Health Malaysia. (2024). National Health and Morbidity Survey (NHMS) 2023. https://iku.nih.gov.my/images/nhms2023/key-findings-nhms-2023.pdf

Ní Chéilleachair, N. J., Harrison, A. J., & Warrington, G. D. (2017). HIIT enhances endurance performance and aerobic characteristics more than high-volume training in trained rowers. Journal of Sports Sciences, 35(11), 1052–1058. https://doi.org/10.1080/02640414.2016.1209539

Nieman, D. C. (1994). Exercise, upper respiratory tract infection, and the immune system. Medicine and Science in Sports and Exercise, 26(2), 128–139. https://doi.org/10.1249/00005768-199402000-00002

Nieman, D. C., & Wentz, L. M. (2019). The compelling link between physical activity and the body’s defense system. Journal of Sport and Health Science, 8, 201–217. https://doi.org/10.1016/j.jshs.2018.09.009

Putro, W. A. S., Hidayatullah, M. F., Doewes, M., Purnama, S. K., Riyadi, S., & Umar, F. (2024). Long-term high-intensity interval training reduces blood glucose in type 2 diabetes mellitus patients. Retos, 60, 653–658. https://doi.org/10.47197/retos.v60.109024

Quaney, B. M., Boyd, L. A., McDowd, J. M., Zahner, L. H., Jianghua He, Mayo, M. S., & MacKo, R. F. (2009). Aerobic exercise improves cognition and motor function poststroke. Neurorehabilitation and Neural Repair, 23(9), 879–885. https://doi.org/10.1177/1545968309338193

Racil, G., Ben Ounis, O., Hammouda, O., Kallel, A., Zouhal, H., Chamari, K., & Amri, M. (2013). Effects of high vs. Moderate exercise intensity during interval training on lipids and adiponectin levels in obese young females. European Journal of Applied Physiology, 113(10), 2531–2540. https://doi.org/10.1007/s00421-013-2689-5

Rafael, J., Monteiro, F., Boscolo, F., Coswig, V. S., & Berny, B. (2020). Specific wushu sanda high-intensity interval training protocol improved physical fitness of amateur athletes’: A pilot study. Revista de Artes Marciales Asiáticas, 14(2), 47–55. https://doi.org/10.18002/rama.v14i2.6029

Ramos, J. S., Dalleck, L. C., Tjonna, A. E., Beetham, K. S., & Coombes, J. S. (2015). The Impact of High-Intensity Interval Training Versus Moderate-Intensity Continuous Training on Vascular Function: a Systematic Review and Meta-Analysis. Sports Medicine, 45(5), 679–692. https://doi.org/10.1007/s40279-015-0321-z

Riebe, D., Ehrman, J., Liguori, G., & Magal, M. (2018). ACSM’s guidelines for exercise testing and prescription. https://library.megu.edu.ua:9443/jspui/handle/123456789/5118

Sahrir, N. A., Ooi, F. K., Chen, C. K., Kyi, W. M., & Meor-Osman, J. (2017). Effects of oat bran and jogging on aerobic capacity, lipid profile and antioxidant parameters in young sedentary males. Journal of Physical Education and Sport, 17(February), 48–59. https://doi.org/10.7752/jpes.2017.s1008

Sawyer, A., Cavalheri, V., & Hill, K. (2020). Effects of high intensity interval training on exercise capacity in people with chronic pulmonary conditions: A narrative review. BMC Sports Science, Medicine and Rehabilitation, 12(1), 1–10. https://doi.org/10.1186/s13102-020-00167-y

Souza, D., Vale, A. F., Silva, A., Araújo, M. A. S., de Paula Júnior, C. A., de Lira, C. A. B., Ramirez-Campillo, R., Martins, W., & Gentil, P. (2021). Acute and Chronic Effects of Interval Training on the Immune System: A Systematic Review with Meta-Analysis. Biology, 10(9). https://doi.org/10.3390/biology10090868

Su, L., Fu, J., Sun, S., Zhao, G., Cheng, W., Dou, C., & Quan, M. (2019). Effects of HIIT and MICT on cardiovascular risk factors in adults with overweight and/or obesity: A meta-analysis. PloS One, 14(1), e0210644. https://doi.org/10.1371/journal.pone.0210644

Sultana, R. N., Sabag, A., Keating, S. E., & Johnson, N. A. (2019). The Effect of Low-Volume High-Intensity Interval Training on Body Composition and Cardiorespiratory Fitness: A Systematic Review and Meta-Analysis. In Sports Medicine (Vol. 49, Issue 11, pp. 1687–1721). Springer International Publishing. https://doi.org/10.1007/s40279-019-01167-w

Susiono, R., Sugiyanto, F. X., Lumintuarso, R., & Tomoliyus, T. (2025). Effect of High-Intensity Interval Training and unification training on Aerobic Capacity and Muscle Strength in Intermediate Distance Runners-a systematic review. Retos, 63, 698–712. https://doi.org/10.47197/retos.v63.111191

Thivel, D., Tremblay, A., Genin, P. M., Panahi, S., Rivière, D., & Duclos, M. (2018). Physical activity, inactivity, and sedentary behaviors: Definitions and implications in occupational health. Frontiers in Public Health, 6(October), 1–5. https://doi.org/10.3389/fpubh.2018.00288

Viana, R. B., Gentil, P., Naves, J. P. A., Rebelo, A. C. S., Santos, D. A. T., Braga, M. A. O., & de Lira, C. A. B. (2019). Interval Training Improves Depressive Symptoms But Not Anxious Symptoms in Healthy Women. Frontiers in Psychiatry, 10, 661. https://doi.org/10.3389/fpsyt.2019.00661

Walsh, N. P., Gleeson, M., Shephard, R. J., Gleeson, M., Woods, J. A., Bishop, N. C., Fleshner, M., Green, C., Pedersen, B. K., Hoffman-Goetz, L., Rogers, C. J., Northoff, H., Abbasi, A., Simon, P., Pyne, D. B., Nieman, D. C., Dhabhar, F. S., Oliver, S. J., Bermon, S., … Tonevitsky, A. G. (2011). From the Editors 5 Position Statement Part one: Immune function and exercise Position Statement Part two: Maintaining immune health A Review of Sex Differences in Immune Function after Aerobic Exercise Exercise Immunology Review, 17, 2011.

Werner, C. M., Hecksteden, A., Morsch, A., Zundler, J., Wegmann, M., Kratzsch, J., Thiery, J., Hohl, M., Bittenbring, J. T., Neumann, F., Böhm, M., Meyer, T., & Laufs, U. (2019). Differential effects of endurance, interval, and resistance training on telomerase activity and telomere length in a randomized, controlled study. European Heart Journal, 40(1), 34–46. https://doi.org/10.1093/eurheartj/ehy585

Wilmore, J. H. (2003). Aerobic exercise and endurance: Improving fitness for health benefits. Physician and Sportsmedicine, 31(5). https://doi.org/10.3810/psm.2003.05.367

World Health Organisation. (2023). Non‐Communicable Diseases. https://doi.org/10.1002/9781118410868.wbehibs407

World Health Organization. (2016). WHO: World Health Organization. World Health Organization. https://doi.org/10.5260/chara.12.4.54

World Health Organization. (2020). WHO Guidelines on physical activity, sedentary behaviour. In World Health Organization. https://apps.who.int/iris/bitstream/handle/10665/325147/WHO-NMH-PND-2019.4-eng.pdf?sequence=1&isAllowed=y%0Ahttp://www.who.int/iris/handle/10665/311664%0Ahttps://apps.who.int/iris/handle/10665/325147

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Publicado

2025-08-14

Cómo citar

Suhaimi, M. Z., Muhamad, A. S., Chen, C. K., Ooi, F. K., Ong, M. L. Y., & Musa, R. M. (2025). Comparación de los efectos inmunológicos y fisiológicos entre el entrenamiento por intervalos de alta intensidad y el entrenamiento continuo de intensidad moderada en adultos físicamente inactivos. Retos, 70, 24–38. https://doi.org/10.47197/retos.v70.115308

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Artículos de carácter científico: investigaciones básicas y/o aplicadas