Efeito da suplementação aguda de ômega 3 reduz os níveis séricos de fator de necrose tumoral alfa (TNF-a), a intensidade da dor e mantém a força muscular após treinamento com pesos de alta intensidade

Autores

  • Novadri Ayubi
  • Bambang Purwanto
  • Purwo Sri Rejeki
  • Nining Widyah Kusnanik
  • Lilik Herawati
  • Toho Cholik Mutohir
  • Anton Komaini Universitas Negeri Padang
  • Nurhasan Nurhasan
  • Muchamad Arif Al Ardha
  • Awang Firmansyah

DOI:

https://doi.org/10.47197/retos.v46.93720

Palavras-chave:

Ômega-3, TNF-α, Intensidade da Dor, Força muscular

Resumo

Este estudo tem como objetivo analisar o efeito agudo da suplementação de ômega 3 nos níveis séricos de TNF-α, intensidade da dor e força muscular após treinamento com pesos de alta intensidade. Um total de 20 homens adultos com IMC de 18,00-24,99 foram incluídos neste estudo. Os indivíduos foram divididos em 2 grupos, a saber (K1) com placebo e (K2) com suplementação de ômega 3 na dose de 1000 mg (540 mg de EPA e 360 ​​mg de DHA). A intervenção foi realizada 24 horas após o treinamento com pesos de alta intensidade. Os dados deste estudo foram coletados antes e após a intervenção. Medição dos níveis séricos de TNF-α usando um kit ELISA humano, medição da intensidade da dor usando escala analógica visual (VAS), medição da força muscular usando um dinamômetro de perna. A técnica de análise de dados é usada se os dados forem normalmente distribuídos, ou seja, teste t pareado e teste t independente, se os dados não tiverem distribuição normal a análise utilizada é o teste de postos sinalizados de Wilcoxon. A suplementação de ômega 3 reduziu significativamente os níveis séricos de TNF-α (p-0,035), reduziu significativamente os níveis de dor (p-0,007) e não diminuiu significativamente a força (p-0,100). A suplementação de ômega 3 pode reduzir os níveis séricos de TNF-α, a intensidade da dor e a suplementação de ômega 3 pode manter a força muscular após o treinamento com pesos de alta intensidade, como evidenciado pela ausência de uma diminuição significativa na força muscular após o treinamento com pesos de alta intensidade.

Referências

Ayubi, N.; Yuniarti, E.; Kusnanik, N.W. et al. Acute effects of n-3 polyunsaturated fatty acids (PUFAs) reducing tumor necrosis factor-alpha (TNF-a) levels and not lowering malondialdehyde (MDA) levels after anaerobic exercise. Journal of Biological Regulators and Homeostatic Agents 2022, 36, 7-11. https://doi.org/10.23812/21-468-A.

Ayubi, N.; Kusnanik, NW.; Herawati, L. et al. Effects of Curcumin on Inflammatory Response During Exercise-Induced Muscle Damage (Literature Review). Biointerface Research in Applied Chemistry 2023, 13, 1-9, https://doi.org/10.33263/BRIAC132.146.

Black, KE.; Witard, OC.; Baker, D, et, al. Adding omega-3 fatty acids to a protein-based supplement during pre-season training results in reduced muscle soreness and the better maintenance of explosive power in professional Rugby Union players. Eur J Sport Sci (2018). 18, 1357-1367. https://doi.org/10.1080/17461391.2018.1491626.

Bumann, A.; Banzer, W.; Fleckenstein, J. Prevalence of biopsychosocial factors of pain in 865 sports students of the dach (Germany, Austria, Switzerland) region – A cross-sectional survey. J Sport Sci Med (2020). 19, 323-336. https://pubmed.ncbi.nlm.nih.gov/32390726/.

Corder, Katherine, E.; Katherine, R.; Newsham, Jennifer, L.; McDaniel, Uthayashanker, R.; Ezekiel, and Edward, P.; Weiss. «Effects of Short-Term Docosahexaenoic Acid Supplementation on Markers of Inflammation after Eccentric Strength Exercise in Women.» Journal of Sports Science and Medicine (2016). 15(1), 176-183. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763838/.

Djuric, Z, Turgeon DK, Sen A, et al. The anti-inflammatory effect of personalized omega-3 fatty acid dosing for reducing prostaglandin E2 in the colonic mucosa is attenuated in obesity. Cancer Prev Res (2017). 10, 729-737. https://doi.org/10.1158/1940-6207.CAPR-17-0091.

Durán, AM.; Salto, LM.; Câmara, J, et, al. Effects of omega-3 polyunsaturated fatty-acid supplementation on neuropathic pain symptoms and sphingosine levels in Mexican-Americans with type 2 diabetes. Diabetes, Metab Syndr Obes Targets Ther (2019). 12, 109-120. https://doi.org/10.2147/DMSO.S187268.

Freitas, Marcelo, Conrado, de.; Jose, Gerosa-Neto.; Nelo, Eidy, Zanchi.; Fabio, Santos, Lira.; and Fabrício, Eduardo, Rossi. «Role of Metabolic Stress for Enhancing Muscle Adaptations: Practical Applications.» World Journal of Methodology (2017). 7(2), 46-54. https://doi.org/10.5662/wjm.v7.i2.46.

Gonzalez-Jurado, Jose A.; Francisco, Pradas, Edgardo, S.; Molina, Carlos, de, Teresa. «Effect of Phlebodium Decumanum on the Immune Response Induced by Training in Sedentary University Students.» Journal of Sports Science and Medicine (2011). 10(2), 315-321. https://pubmed.ncbi.nlm.nih.gov/24149877/.

Gutiérrez-Pliego, LE.; Martínez-Carrillo, BE.; Reséndiz-Albor, AA, et, al. Effect of Supplementation with n -3 Fatty Acids Extracted from Microalgae on Inflammation Biomarkers from Two Different Strains of Mice . J Lipids (2018). 1, 1-7. https://doi.org/10.1155/2018/4765358.

Haidari, F.; Abiri, B.; Iravani, M, et, al. Effects of vitamin D and omega-3 fatty acids co-supplementation on inflammatory biomarkers, tumor marker CEA, and nutritional status in patients with colorectal cancer: A study protocol for a double blind randomized controlled trial. Trials (2019). 20, 1-7. https://doi.org/10.1186/s13063-019-3719-3.

Heiss, R.; Hotfiel, T.; Kellermann, M, et al. Effect of compression garments on the development of edema and soreness in delayed-onset muscle soreness (DOMS). J Sport Sci Med (2018). 17, 392-401. https://pubmed.ncbi.nlm.nih.gov/30116112/.

Juhasz, I.; Kopkane, JP.; Hajdu, P.; Szalay, G.; Kopper, B.; Tihanyi, J. Creatine supplementation supports the rehabilitation of adolescent fin swimmers in tendon overuse injury cases. J Sport Sci Med (2018). 17, 279-288. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5950745/.

Jürgenson, J.; Serg, M.; Kampus, P, et, al. Effect of Half-Marathon Running on Arterial Stiffness and Blood Biomarkers in High-Level and Recreational Male Athletes. J Sport Sci Med (2021). 20, 548-556. https://doi.org/1052082/jssm.2021.548.

Khan, SA. Effects of Short Term Supplementation of Fish Oil Capsules on the Blood Fatty Acid Profile of Vegetarians/ : A Pilot Study (2017). 6, 19-23. ISSN No: 2319-5886.

Kim, J.; Kim, J.; Lee, J. Effect of compression garments on delayed-onset muscle soreness and blood inflammatory markers after eccentric exercise: A randomized controlled trial. J Exerc Rehabil (2017). 13, 541-545. https://doi.org/10.12965/jer.1735088.554.

Kim, J.; Lee, J. A review of nutritional intervention on delayed onset muscle soreness. Part I. J Exerc Rehabil (2014). 10, 349-356, https://doi.org/10.12965/jer.140179.

Kyriakidou, Yvoni.; Carly, Wood.; Chrystalla, Ferrier.; Alberto, Dolci.; Bradley, Elliott. «The Effect of Omega-3 Polyunsaturated Fatty Acid Supplementation on Exercise-Induced Muscle Damage.» Journal of the International Society of Sports Nutrition (2021). 18(1), 1-12. https://doi.org/10.1186/s12970-020-00405-1.

Lulińska-Kuklik, Ewelina, Maculewicz.; Waldemar, Moska.; Krzysztof, Ficek.; Mariusz, Kaczmarczyk, Monika, MichaBowska-Sawczyn.; Kinga, Humińska-Lisowska, et al. «Are IL1B, IL6 and IL6R Gene Variants Associated with Anterior Cruciate Ligament Rupture Susceptibility?» Journal of Sports Science and Medicine (2019). 8(1), 137-145. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370956/pdf/jssm-18-137.

Meital, Lara, T.; Mark, T.; Windsor.; Maria, Perissiou.; Karl, Schulze.; Rebecca, Magee.; Anna, Kuballa.; Jonathan, Golledge.; Tom, G.; Bailey, Christopher, D.; Askew.; Fraser, D.; Russell. «Omega-3 Fatty Acids Decrease Oxidative Stress and Inflammation in Macrophages from Patients with Small Abdominal Aortic Aneurysm.» Scientific Reports (2019). 9(12978), 1-11. https://doi.org/10.1038/s41598-019-49362-z.

Mittal, Sharad, K..; Paul, A.; Roche. «Suppression of Antigen Presentation by IL-10.» Current Opinion in Immunology (2015). 24(1), 22-27. https://doi.org/10.1016/j.coi.2014.12.009.

Ozaki, Hayao.; Takashi, Nakagata.; Toshinori, Yoshihara.; Tomoharu, Kitada.; Toshiharu, Natsume.; Yoshihiko, Ishihara.; Pengyu, Deng.; Hiroyuki, Kobayashi.; Shuichi, Machida.; Hisashi. Naito. «Effects of Progressive Walking and Stair-Climbing Training Program on Muscle Size and Strength of the Lower Body in Untrained Older Adults.» Journal of Sports Science and Medicine (2019). 18(4), 722-728. https://pubmed.ncbi.nlm.nih.gov/31827357/.

Ozaki, Hayao.; Shuji, Sawada.; Takuya, Osawa.; Toshiharu, Natsume.; Toshinori, Yoshihara.; Pengyu Deng.; Shuichi, Machida.; Hisashi, Naito. «Muscle Size and Strength of the Lower Body in Supervised and in Combined Supervised and Unsupervised Low-Load Resistance Training.» Journal of Sports Science and Medicine (2020). 19(4), 721-726. https://pubmed.ncbi.nlm.nih.gov/33239946/.

Sari, S. Mengatasi DOMS Setelah Berolahraga. Dosen IKIP PGRI PONTIANAK (2016). 97-107. https://adoc.pub/mengatasi-doms-setelah-olahraga-suriani-sari-1-ikip-pgri-pon.html.

Schoenfeld, BJ. The use of nonsteroidal anti-inflammatory drugs for exercise-induced muscle damage: Implications for skeletal muscle development. Sport Med (2012). 42, 1017-1028. https://doi.org/10.1007/BF03262309.

Smith, GI.; Julliand, S.; Reeds, DN.; Sinacore, DR.; Klein, S.; Mittendorfer B. Fish oil-derived n-3 PUFA therapy increases muscle mass and function in healthy older adults. Am J Clin Nutr (20150. 102, 115-122. https://doi.org/10.3945/ajcn.114.105833.

Stojanović, MDM.; Mikić, M.; Milošević, Z.; Vuković, J.; Jezdimirović, T.; Vučetić, V. Effects of chair-based, low–load elastic band resistance training on functional fitness and metabolic biomarkers in older women. J Sport Sci Med (2021). 20, 133-141. https://doi.org/10.52082/jssm.2021.133.

Tachtsis, B. Camera, D.; Lacham-Kaplan, O. Potential roles of n-3 PUFAs during skeletal muscle growth and regeneration. Nutrients (2018). 10, 1-20. https://doi.org/10.3390/nu10030309.

Williams-Bey.; Yolanda, Cedric, Boularan.; Ali, Vural.; Ning, Na, Huang.; Il, Young, Hwang.; Chong, Shan-Shi.; John, H, Kehrl. «Omega-3 Free Fatty Acids Suppress Macrophage Inflammasome Activation by Inhibiting NF-ΚB Activation and Enhancing Autophagy.» PLoS ONE (2014). 9(6), 1-8. https://doi.org/10.1371/journal.pone.0097957.

Yoon, Wan-Young.; Kihyuk, Lee.; Jooyoung, Kim. «Curcumin Supplementation and Delayed Onset Muscle Soreness (DOMS): Effects, Mechanisms, and Practical Considerations.» Physical Activity and Nutrition (2020). 24(3), 39-43. https://doi.org/10.20463/pan.2020.0020.

Żebrowska, A.; Mizia-Stec, K.; Mizia, M.; Gąsior, Z.; Poprzęcki, S. Omega-3 fatty acids supplementation improves endothelial function and maximal oxygen uptake in endurance-trained athletes. Eur J Sport Sci (2015). 15, 305-314. https://doi.org/10.1080/17461391.2014.949310.

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Publicado

28-09-2022

Edição

Secção

Artigos de caráter científico: trabalhos de pesquisas básicas e/ou aplicadas.

Como Citar

Ayubi, N. ., Purwanto, B. ., Rejeki, P. S. ., Kusnanik, N. W. ., Herawati, L. ., Mutohir, T. C. ., Komaini, A., Nurhasan, N., Al Ardha, M. A. ., & Firmansyah, A. . (2022). Efeito da suplementação aguda de ômega 3 reduz os níveis séricos de fator de necrose tumoral alfa (TNF-a), a intensidade da dor e mantém a força muscular após treinamento com pesos de alta intensidade. Retos, 46, 677-682. https://doi.org/10.47197/retos.v46.93720