A erva-mate e o ácido clorogénico reduzem a ansiedade e os défices cognitivos causados pelo destreino em ratinhos
DOI:
https://doi.org/10.47197/retos.v63.107820Palavras-chave:
Ácido clorogénico, ansiedade, depressão, erva-mateResumo
Objectivo: No presente estudo investigámos se a administração de Erva Mate (YM) e de um dos seus componentes bioactivos, o ácido clorogénico, são capazes de reverter as alterações comportamentais negativas induzidas pelo destreinoMetodologia: Para tal, os animais foram divididos aleatoriamente em cinco grupos experimentais (n=10): grupo sedentário, grupo treinado, grupo destreino, grupo destreino tratado com erva-mate e grupo destreino tratado com ácido clorogénico. O grupo treinado realizou treino de natação durante 8 semanas (5 dias/semana, 60 min/dia), enquanto os grupos de destreino realizaram o mesmo programa de natação durante 4 semanas e depois interromperam o exercício durante 4 semanas. Os animais foram pesados semanalmente durante o tratamento. Após 8 semanas, os indivíduos foram submetidos a uma bateria de testes comportamentais, incluindo: campo aberto, tarefa de reconhecimento de objetos, caixa claro-escuro e teste de suspensão da cauda. grupo destreino e o grupo destreinado. Também foi demonstrado que a atividade física promoveu um efeito antidepressivo nos ratos treinados. No entanto, o destreino prolongado elimina este efeito. Além disso, o destreino provoca um aumento do comportamento semelhante ao da ansiedade em comparação com o grupo treinado e um comprometimento da memória em comparação com os ratos sedentários e treinados. Curiosamente, estes efeitos prejudiciais induzidos pelo destreino são parcialmente revertidos pelo tratamento com erva-mate ou ácido clorogénico. Não foi observada qualquer diferença no teste de campo aberto. Conclusões: Portanto, a erva-mate e o ácido clorogénico revertem parcialmente as alterações comportamentais e o prejuízo cognitivo causado pelo destreino.
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